WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Calcium signaling pathway       ID:04020
C=177; O=5; E=0.39; R=12.82; rawP=4.73e-05; adjP=0.0004
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000108405 NA P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1 5023 ENSG00000108405
2  ENSG00000169252 NA ADRB2 adrenoceptor beta 2, surface 154 ENSG00000169252
3  ENSG00000164270 NA HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3360 ENSG00000164270
4  ENSG00000178568 NA ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 2066 ENSG00000178568
5  ENSG00000135914 NA HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 3357 ENSG00000135914


Database:KEGG pathway       Name:Neuroactive ligand-receptor interaction       ID:04080
C=272; O=6; E=0.60; R=10.01; rawP=3.24e-05; adjP=0.0004
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000108405 NA P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1 5023 ENSG00000108405
2  ENSG00000108556 NA CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 1145 ENSG00000108556
3  ENSG00000105737 NA GRIK5 glutamate receptor, ionotropic, kainate 5 2901 ENSG00000105737
4  ENSG00000169252 NA ADRB2 adrenoceptor beta 2, surface 154 ENSG00000169252
5  ENSG00000164270 NA HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3360 ENSG00000164270
6  ENSG00000135914 NA HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 3357 ENSG00000135914


Database:KEGG pathway       Name:Axon guidance       ID:04360
C=129; O=4; E=0.28; R=14.08; rawP=0.0002; adjP=0.0011
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000065320 NA NTN1 netrin 1 9423 ENSG00000065320
2  ENSG00000107731 NA UNC5B unc-5 homolog B (C. elegans) 219699 ENSG00000107731
3  ENSG00000116106 NA EPHA4 EPH receptor A4 2043 ENSG00000116106
4  ENSG00000076356 NA PLXNA2 plexin A2 5362 ENSG00000076356


Database:KEGG pathway       Name:Endocytosis       ID:04144
C=201; O=4; E=0.44; R=9.03; rawP=0.0010; adjP=0.0025
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000169252 NA ADRB2 adrenoceptor beta 2, surface 154 ENSG00000169252
2  ENSG00000131242 NA RAB11FIP4 RAB11 family interacting protein 4 (class II) 84440 ENSG00000131242
3  ENSG00000178568 NA ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 2066 ENSG00000178568
4  ENSG00000164695 NA CHMP4C charged multivesicular body protein 4C 92421 ENSG00000164695


Database:KEGG pathway       Name:Gap junction       ID:04540
C=90; O=3; E=0.20; R=15.13; rawP=0.0011; adjP=0.0025
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000164116 NA GUCY1A3 guanylate cyclase 1, soluble, alpha 3 2982 ENSG00000164116
2  ENSG00000061918 NA GUCY1B3 guanylate cyclase 1, soluble, beta 3 2983 ENSG00000061918
3  ENSG00000135914 NA HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 3357 ENSG00000135914


Database:KEGG pathway       Name:ErbB signaling pathway       ID:04012
C=87; O=3; E=0.19; R=15.65; rawP=0.0010; adjP=0.0025
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000157168 NA NRG1 neuregulin 1 3084 ENSG00000157168
2  ENSG00000185634 NA SHC4 SHC (Src homology 2 domain containing) family, member 4 399694 ENSG00000185634
3  ENSG00000178568 NA ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 2066 ENSG00000178568


Database:KEGG pathway       Name:Salivary secretion       ID:04970
C=89; O=3; E=0.20; R=15.30; rawP=0.0010; adjP=0.0025
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000169252 NA ADRB2 adrenoceptor beta 2, surface 154 ENSG00000169252
2  ENSG00000164116 NA GUCY1A3 guanylate cyclase 1, soluble, alpha 3 2982 ENSG00000164116
3  ENSG00000061918 NA GUCY1B3 guanylate cyclase 1, soluble, beta 3 2983 ENSG00000061918


Database:KEGG pathway       Name:Long-term depression       ID:04730
C=70; O=2; E=0.15; R=12.97; rawP=0.0105; adjP=0.0210
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000164116 NA GUCY1A3 guanylate cyclase 1, soluble, alpha 3 2982 ENSG00000164116
2  ENSG00000061918 NA GUCY1B3 guanylate cyclase 1, soluble, beta 3 2983 ENSG00000061918


Database:KEGG pathway       Name:Small cell lung cancer       ID:05222
C=85; O=2; E=0.19; R=10.68; rawP=0.0152; adjP=0.0243
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000050555 NA LAMC3 laminin, gamma 3 10319 ENSG00000050555
2  ENSG00000143171 NA RXRG retinoid X receptor, gamma 6258 ENSG00000143171


Database:KEGG pathway       Name:Protein digestion and absorption       ID:04974
C=81; O=2; E=0.18; R=11.21; rawP=0.0139; adjP=0.0243
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000197635 NA DPP4 dipeptidyl-peptidase 4 1803 ENSG00000197635
2  ENSG00000112394 NA SLC16A10 solute carrier family 16, member 10 (aromatic amino acid transporter) 117247 ENSG00000112394




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).